INCREASED ZINC AND MANGANESE IN PARALLEL WITH NEURODEGENERATION, SYNAPTIC PROTEIN CHANGES AND ACTIVATION OF AKT/GSK3 SIGNALING IN OVINE CLN6 NEURONAL CEROID LIPOFUSCINOSIS.

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.

Mutations in the CLN6 gene cause a variant late infantile form of neuronal ceroid lipofuscinosis (NCL; Batten disease).CLN6 loss leads to disease clinically characterized by vision impairment, motor and cognitive dysfunction, and seizures.Accumulating evidence suggests that alterations honey filled cough drops in metal homeostasis and cellular sign

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